Improving Egg Quality After 35: Egg Maturation, The Factors That Influence Egg Quality, & How To Build Robust Fertility At 35+

Improving Egg Quality After 35: Egg Maturation, The Factors That Influence Egg Quality, & How To Build Robust Fertility At 35+

The journey to conceiving a healthy baby can be filled with ups and downs, especially when considering the nuances of egg quality after 35. However, in my nearly 30-year-long career as a scientist and fertility expert, I’ve had the incredible opportunity of discovering new, groundbreaking truths about pregnancy over 35 and helping women from ages 28 – 47 have their healthy superbabies.

Age significantly impacts female reproductive capacity and viability, with diminishing egg reserves, quality, and health. This decline heightens drastically when we near our 40s. We also know this isn’t concrete or set in stone thanks to the research and scientific evidence of our ability to make positive epigenetic changes, facilitating your healthiest pregnancy, baby, and future long life. Today, we’ll explore the vital process of egg maturation, how egg quality is influenced, and how to sway that influence positively to effect the needed epigenetic changes. Are you ready to dive in with me?

Improving Egg Quality After 35 & Understanding Egg Maturation

It’s awe-inspiring to consider that the blueprint for your future offspring and even your grandchildren was intricately woven into the fabric of your existence long before you took your first breath. Your reproductive system developed when you were a 20-week-old fetus, complete with eggs that will become your baby when the time comes. When we consider the concept of carrying future generations within us, it’s a testament to the profound interconnectedness of life, which speaks volumes about the intergenerational transmission of health.

Oogenesis, the process of egg development in females, commences even before birth and spans a lifetime. It’s an intricate sequence involving various stages, each pivotal in shaping the potential for future life. The significance of egg quality cannot be overstated. It encompasses an egg’s genetic and structural integrity, determining its ability to be fertilized and develop into a healthy embryo. As age progresses, the risk of chromosomal abnormalities rises, impacting the success of conception (Owen & Sparzak, 2022). Understanding these aspects is crucial if you’re trying to improve your egg quality after 35. 

Before diving into the maturation process, I want to tell you about how you can actively improve your egg quality after 35 and protect your body, pregnancy, and baby from age-related conditions that can make the idea of conception after 35 seem far-fetched. Prime Vitamin D with K1 and K2 significantly boosts egg quality through its diverse advantages. Acting as a hormone, Prime Vitamin D with K1 and K2 directly influences follicle and egg development, which is crucial for fertility. Low Vitamin D levels correlate with fertility issues, while optimal levels reduce risks of preterm birth, thanks to immune and calcium regulation (Meng et al., 2023). Higher maternal Vitamin D during pregnancy benefits children’s health by lowering autoimmune risks like multiple sclerosis. With essential vitamins K1 and K2 supporting bone health and preventing deficiencies during pregnancy, this supplement safely enhances fertility and egg quality.

Get Prime Vitamin D with K1 and K2 today.

The Egg Maturation Process

Primordial Follicles Formation:

During early fetal development, the ovaries house primordial germ cells, which are the precursors to eggs. These cells go through several divisions and start forming clusters of cells called primordial follicles (Wear et al., 2016). Each of these follicles contains an immature egg cell, or oocyte, in a dormant state.

Primary Follicle Development:

Some of these primordial follicles are activated as a female progresses through childhood into puberty. The activated follicles undergo a transformation into primary follicles (Williams & Erickson, 2000). The oocyte within the primary follicle grows and is now surrounded by layers of specialized cells called granulosa cells. These cells provide nourishment and support to the developing egg.

Secondary Follicle Formation:

Inside the primary follicle, a fluid-filled cavity begins to form, creating a structure known as a secondary follicle. This cavity called an antrum, continues to expand, and the granulosa cells divide into two distinct layers: the inner cumulus oophorus, which encases the egg, and the outer theca cells, providing hormonal support.

Graafian Follicle Maturation:

Among the secondary follicles, one becomes dominant due to hormonal signals. This dominant follicle matures into what’s known as the Graafian follicle. The oocyte within this follicle undergoes final maturation, acquiring the ability to be released during ovulation.


Hormonal surges, particularly luteinizing hormone (LH), trigger the Graafian follicle to rupture, releasing the matured egg from the ovary. This process is ovulation and typically occurs around the middle of the menstrual cycle (NHS, 2018).

Fate of the Egg:

The egg travels down the fallopian tube upon release. If fertilization occurs during this journey by a sperm cell, it forms a zygote, marking the beginning of a new life. If not fertilized within a certain timeframe, the egg disintegrates, and the menstrual cycle continues.

This intricate process, spanning decades and involving precise hormonal regulation and cellular interactions, showcases the meticulous orchestration required to create and release a single egg. It’s an exquisite illustration of the complexity and beauty inherent in the creation of life, showcasing the marvels of human reproduction. 

To help nurture your developing superbaby, I’d like to introduce you to Prime GlycerophosphoCHOLINE. It is a pivotal asset for fertility, pregnancy, and beyond. It fosters cell growth and fetal brain development as a crucial cellular membrane component. Its supplementation during pregnancy lowers the risk of attention issues and enhances children’s social engagement. 

Beyond brain health, it supports liver function, aids fertility in both men and women and assists in absorbing fat-soluble nutrients. This supplement offers holistic support for brain, gut, and cardiovascular health, making it integral for comprehensive fertility and pregnancy care, especially in improving egg quality after 35.

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Factors Impacting Egg Quality and Fertility

Navigating fertility challenges beyond age 35 involves acknowledging the impact of advanced maternal age on declining egg quality. Egg quality and quantity decline significantly as women age. While the average oocyte count at age 35 is 12, this number decreases to 10 at 36, 8 at 37, 6 at 38, 4 at 39, and only 2 at 40 (ACOG, 2014). This decline is accompanied by a decrease in oocyte quality, with oocyte quality at age 35 being considered “good,” while oocyte quality at age 36 is considered “fair,” and oocyte quality at age 37 and beyond is considered “poor.”

Strategies to improve egg quality after 35 include understanding, addressing, and managing multifaceted factors. This is crucial in optimizing egg quality and fertility after 35 and will empower you in navigating age-associated fertility concerns.

  • Advanced Maternal Age: Improving egg quality after 35 can become a challenge due to the natural decline in the quantity and quality of eggs as women age. While age-related changes are inevitable, through the study of epigenetics, we now know that certain lifestyle and nutritional adjustments can help you foster the fertility outcomes you desire for as many superbabies as you desire (Sgueglia et al., 2023). Let our Complete Mama Bundle be your support and ally in reversing the effects of reproductive aging and improving egg quality after 35 for your healthiest fertility.
  • Ovulatory Dysfunction: Addressing ovulatory issues is crucial in improving egg quality after 35. Techniques such as hormonal therapies, lifestyle changes (such as maintaining a healthy weight and reducing stress), and medications prescribed by a healthcare provider can help regulate ovulation, potentially enhancing egg quality. Prime Vitamin D with K1 and K2 is an essential fertility asset that regulates hormones for ovulation, maintaining a healthy uterine lining, reducing miscarriage risks, preventing preterm birth, supporting fetal bone development, and mood regulation postpartum.
  • Chromosomal Abnormalities: While age-related chromosomal abnormalities are largely unavoidable, preconception genetic counseling and, in some cases, advanced reproductive techniques like preimplantation genetic testing can help identify abnormal embryos, thus improving the chances of a successful pregnancy and allowing time for improving egg quality after 35 (Cimadomo et al., 2018). Extra Neural Tube & Chromosomal Care offers comprehensive protection against chromosomal abnormalities and neural tube defects. The supplement duo supports fertility by reducing inflammation and preventing miscarriages, abnormalities, and neural tube defects. These supplements enhance reproductive health, affecting specific factors like improving egg quality after 35, improving DNA quality, supporting healthy fertility in men and women, improving IVF outcomes, and reducing risks related to PCOS, obesity, and insulin resistance.
  • Decreased Ovarian Reserve: Although the decline in ovarian reserve is a natural part of aging, certain supplements and medications, along with fertility preservation techniques like egg freezing at a younger age, may assist in mitigating the impact of reduced ovarian reserve and improving egg quality after 35. Folate, vitamin D, omega-3 fatty acids, and antioxidants collectively combat decreased ovarian reserve. Vitamin D regulates ovulation hormones, addressing irregular periods and infertility. Folate supports DNA synthesis and healthy egg development, reducing chromosomal abnormality risks and improving egg quality after 35. Omega-3s reduce inflammation, in turn improving egg quality. This is especially essential for women with PCOS. Antioxidants like vitamins C, E, and selenium protect ovarian cells from damage, crucial for preserving ovarian health. Including antioxidant-rich foods aids in reversing decreased ovarian reserve. You can find these natural fertility helpers and more in our range of Superbaby Nutraceuticals.
  • Changes in Hormone Levels: Balancing hormones through personalized hormonal therapies or medications under the guidance of a healthcare professional can be beneficial for improving egg quality after 35. This could involve hormone replacement therapy or medications to support ovarian function. Prime Pre-Pregnancy & Prenatal, a pioneering prenatal blend, supports fertility, pregnancy, and postpartum care. Mimicking an ancestral diet offers crucial nutrients for hormonal balance and reproductive health. Especially beneficial for those over 35, it fosters hormonal equilibrium and enhances egg quality, notably through key nutrients like vitamin D, which is crucial for reproductive health. This supplement ensures comprehensive support through fertility, pregnancy, and beyond.
  • Cumulative Environmental Exposures: Minimizing exposure to environmental toxins and pollutants can be beneficial in preserving egg quality (Canipari et al., 2020). Adopting a lifestyle that reduces exposure, such as consuming organic foods, using toxin-free household products, and avoiding environmental pollutants, can potentially contribute to improving egg quality after 35. Prime GlycerophosphoCHOLINE, rich in choline, significantly enhances egg quality after 35 by shielding against toxins and supporting reproductive health. It safeguards cell integrity, is vital for egg protection, and regulates homocysteine for improved oocyte development and fertility. Its impact on DNA methylation notably enhances egg quality. Supported by robust evidence, Prime GlycerophosphoCHOLINE offers a proven approach to elevate egg health in older women when complemented by a holistic lifestyle for optimal reproductive well-being.
  • Lifestyle Factors: Making healthy lifestyle choices, such as quitting smoking, eliminating alcohol consumption, exercising regularly, and maintaining a balanced diet rich in antioxidants and essential nutrients is vital in improving egg quality after age 35 (Sharma et al., 2013).
  • Nutritional Status: Ensuring adequate intake of nutrients vital for reproductive health, such as folate, iron, omega-3 fatty acids, and antioxidants, through a well-balanced diet or supplements can be an incredible aid for improving egg quality after 35. Consulting with a nutritionist or healthcare provider for personalized advice is advisable. To adequately support your nutrient status and ensure you’re receiving the 5 essential nutrients your body needs to foster internal balance, get the Complete Mama & Dada Bundle for you and your partner or donor. This will help you address the foundational aspects of your fertility in order to build and boost your fertility efficiently. 
  • Body Mass Index (BMI): Maintaining a healthy BMI within the recommended range can be pivotal for improving egg quality after 35. For some women, achieving a healthier weight through diet and exercise might improve fertility outcomes and egg quality. It’s important to note that being underweight may require gaining weight to have the desired BMI for healthy fertility. With our renowned Primemester Protocol, you’ll get to learn more about what a healthy BMI means for your body, along with every practice to help you harness your FULL fertile potential for your healthiest baby and future.
  • Medical Conditions: Managing medical conditions that can affect fertility, such as PCOS or endometriosis, through appropriate treatments and medications can help improve egg quality after 35. Seeking specialized care from healthcare professionals familiar with reproductive health concerns is essential. Extra Neural Tube & Chromosomal Care offers a comprehensive approach for managing conditions like PCOS or endometriosis, potentially improving egg quality after 35. It addresses nutrient deficiencies linked to infertility, reduces inflammation and oxidative stress, supports hormonal balance, and targets issues such as obesity and insulin resistance impacting fertility. 
  • Stress: Employing stress management techniques like yoga, meditation, mindfulness, or counseling can help manage stress levels, potentially positively influencing hormonal balance and, subsequently, improving egg quality after 35. For adequate emotional support, joining our loving FPI Village can give you the solace you need, knowing you are not alone on this often triggering path. Here, you will find a home and community of women who are all either on the quest to become a Mama or have achieved their dreams through our offerings. 

Are you searching for a way to get a personalized plan for your fertility based on your DNA and data that you can follow and be guided through by an expert? With our highly personalized PrimeDNA service, you can get intimate details about your DNA and genetic makeup through testing and work with a specialist to help you analyze your data to build a program to adequately suppress weak genes and accentuate the stronger ones you want to pass on to your baby.

Get started with PrimeDNA today.

Improving Egg Quality After 35 With Proven Supplements

If you’ve encountered my teachings previously, you’re likely aware of my strong emphasis on the harmony between mind and body wellness, a cornerstone for robust fertility, a healthy pregnancy, and nurturing a future superbaby and long life. The information, resources, and practices I offer you today are grounded in science and have allowed me to meticulously plan, create, and nurture my three superbabies exactly as envisioned. I’m here to help you do the same, Mama. 

The supplements I’m about to share with you can all be found in our Complete Mama Bundle, each thoughtfully included because of the incredible benefits these nutrients have for your overall health and reproductive well-being. These 5 essential nutrients work at the nutritional level to foster balance and help reverse biological aging, enabling you to work on specific factors of your fertility, like improving egg quality after 35.

Get the Complete Mama Bundle today!

6 Nutrients & Supplements For Improving Fertility & Egg Quality After 35

1. Antioxidants (Vitamins C, E, and Selenium):

Antioxidants are vital for countering oxidative stress and potentially beneficial for egg quality. Vitamin C, found in citrus fruits and vegetables, helps neutralize free radicals. Vitamin E, present in nuts and seeds, also serves as an antioxidant, protecting cells from damage. Selenium, found in nuts, seeds, and seafood, supports the body’s antioxidant defenses (Lima et al., 2022). For a potent balance of these nutrients and more, our Prime Pre-Pregnancy & Prenatal is carefully sourced to support your fertility, pregnancy, and beyond.

2. Omega-3 Fatty Acids:

Rich in fish oil, omega-3 fatty acids offer anti-inflammatory properties and support overall reproductive health. They’re believed to impact egg quality and hormonal balance positively. With our Prime DHA, you’ll get an essential blend of the most beneficial form of these fatty acids.

3. Vitamin D:

Essential for bone health and immune function, Vitamin D also plays a role in reproductive health. It’s involved in hormone regulation and supports the overall well-being of the reproductive system. Get an adequate dose of vitamin D with our Prime Vitamin D with K1 and K2 and reap the benefits of fertility health.

4. Folate:

Found in leafy greens, beans, and fortified grains, folate is critical for preventing neural tube defects in early pregnancy and supports healthy fetal development. With our Prime Methylated B12 + Folate and Prime Methylated Folate Extra, you’ll nourish your body with the most essential form of folate, which is bioavailable and ready for your body to benefit from immediately.

5. Iron:

Essential for transporting oxygen in the blood, iron supports overall health and adequate blood flow, which is crucial for reproductive health. Prime Pre-Pregnancy & Prenatal is a nutrient-dense comprehensive prenatal and fertility aid enriched with essential nutrients like iron to give you the balance your body needs.

6. B Vitamins (B6, B12, B9):

These vitamins are involved in various cellular processes and may impact reproductive health (Chavarro et al., 2008). B6 supports hormone regulation, B12 contributes to DNA synthesis, and B9 (folate) aids in cell division and growth. Our Prime B Complex is made to specifically include all of the essential B vitamins in their most bioidentical and bioavailable for your body’s immediate use and benefit.

When obtained through a balanced diet supported by healthier lifestyle modifications and proven fertility supplements,  these nutrients contribute to reproductive health and aid in improving egg quality after 35. Empower yourself with the ability to reshape your fertility outcomes and steer your genetic expression in your favor. And the information I shared with you today is a secret as to how you can tap into your FULL reproductive potential. To help you remember all the crucial points I discussed to help you improve your egg quality, I’ve made you a checklist. Get your FREE Improving Egg Quality After 35 Checklist and start incorporating these aids into your routine for the baby, family life, and long-term health you deserve.

Get your checklist here, Precious Mama-in-the-making.

The Key To Improving Egg Quality After 35

Understanding the complexities of egg quality, the critical phases in embryonic development, and the multitude of factors influencing fertility empowers you on your journey toward conception. While age and genetics play significant roles, proactive lifestyle changes, nutritional adjustments, and selective supplementation offer promising avenues for enhancing egg quality and fertility. Seeking personalized guidance from healthcare professionals ensures a tailored approach toward a healthy pregnancy.

Take advantage of the complimentary knowledge I share with you and rest on my years of dedication and expertise. Pregnancy after 35 can be an intimidating path to walk, and knowing that you have someone to guide you through each step can be the assurance you need to believe in your dreams of becoming a Mama, even at 40+. To help you, I’d like you to book a complimentary Fertility & Pregnancy consultation today. Speak to a member of your highly specialized FPI Team and gain sound advice for achieving your fertility and baby goals.

Consult your highly specialized FPI Team here.

Sent with superbaby dust,

Dr. Cleopatra.

Dr. Cleopatra Kamperveen, a pioneering scientist and university professor, leads the charge in reproductive health as the Fertility Strategist and Executive Director of The Fertility & Pregnancy Institute. Her groundbreaking work focuses on fertility biohacking, shaping what she terms “Superbabies.” Through her In Bloom programs and personalized consultations, she empowers global families, emphasizing mindset shifts alongside physical health for conception readiness. Dr. Cleopatra’s extensive research explores how we shape gene expression for future generations. Her Primemester Protocol unlocks the preconceptional window, enabling us to optimize gene quality and inheritance. Beyond science, she champions the healing of intergenerational trauma, urging women to seize this transformative moment for their progeny’s health.


Q1: How does age impact egg quality after 35?

A1: Age significantly affects egg quantity, quality, and health, with diminishing reserves and increased risks of chromosomal abnormalities as women approach their 40s.

Q2: What is the egg maturation process?

A2: Egg maturation involves stages like primordial follicle formation, primary follicle development, secondary follicle formation, Graafian follicle maturation, ovulation, and the fate of the egg, showcasing the complexity of human reproduction.

Q3: How can I improve egg quality after 35 through supplements?

A3: Supplements like Prime Vitamin D with K1 and K2, Prime GlycerophosphoCHOLINE, and others support follicle development, hormonal regulation, and brain health and protect against toxins, benefiting egg quality after 35.

Q4: What factors impact egg quality and fertility after 35?

A4: Advanced maternal age, ovulatory dysfunction, chromosomal abnormalities, decreased ovarian reserve, hormone fluctuations, environmental exposures, lifestyle choices, nutritional status, BMI, medical conditions, and stress can influence egg quality after 35.

Q5: Can supplements mitigate decreased ovarian reserve?

A5: Supplements rich in folate, vitamin D, omega-3 fatty acids, and antioxidants might aid in combatting decreased ovarian reserve and enhancing egg quality after 35. Get the Complete Mama Bundle for a comprehensive package of all your nutritional aids.

Q6: How do hormonal imbalances affect egg quality after 35?

A6: Balancing hormones through therapies like Prime Pre-Pregnancy & Prenatal can positively impact egg quality, supporting hormonal equilibrium crucial for reproductive health after 35.

Q7: What role do lifestyle choices play in improving egg quality after 35?

A7: Adopting healthy habits like quitting smoking, moderating alcohol intake, regular exercise, and maintaining a balanced diet rich in antioxidants and nutrients can significantly benefit egg quality after 35.

Q8: Can supplements like Prime GlycerophosphoCHOLINE protect against environmental toxins?

A8: Yes, supplements rich in choline, like Prime GlycerophosphoCHOLINE, shield against toxins, supporting egg quality after 35 and reproductive health.

Q9: How crucial is nutritional status for improving egg quality after 35?

A9: Ensuring adequate intake of nutrients like folate, iron, omega-3 fatty acids, and others either through diet or supplements, is essential for reproductive health and egg quality after 35.

Q10: What steps can be taken to manage stress impacting egg quality after 35?

A10: Employing stress management techniques like yoga, meditation, or counseling can help manage stress levels, potentially influencing hormonal balance and egg quality after 35.


ACOG. (2014, March). Female age-related fertility decline.

Canipari, R., De Santis, L., & Cecconi, S. (2020). Female fertility and environmental pollution. International Journal of Environmental Research and Public Health, 17(23), 8802.

Chavarro, J. E., Rich-Edwards, J. W., Rosner, B. A., & Willett, W. C. (2008). Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility. Fertility and Sterility, 89(3), 668–676.

Cimadomo, D., Fabozzi, G., Vaiarelli, A., Ubaldi, N., Ubaldi, F. M., & Rienzi, L. (2018). Impact of maternal age on oocyte and embryo competence. Frontiers in Endocrinology, 9.

Lima, L. G., Santos, A. A. M. dos, Gueiber, T. D., Gomes, R. Z., Martins, C. M., & Chaikoski, A. C. (2022). Relation between selenium and female fertility: A systematic review. Revista Brasileira de Ginecologia E Obstetrícia, 44, 701–709.

Medcell Yale. (n.d.). Graafian follicle. Retrieved November 29, 2023, from

Meng, X., Zhang, J., Wan, Q., Huang, J., Han, T., Qu, T., & Yu, L. (2023). Influence of Vitamin D supplementation on reproductive outcomes of infertile patients: a systematic review and meta-analysis. Reproductive Biology & Endocrinology, 21(1), 1–16.

NHS. (2018, June 27). How can I tell when i’m ovulating? NHS UK.

Owen, A., & Sparzak, P. B. (2022). Age related fertility decline. PubMed; StatPearls Publishing.

Paxton, S., Peckham, M., & Knibbs, A. (2003). The leeds histology guide.

Sgueglia, G., Longobardi, S., Valerio, D., Campitiello, M. R., Colacurci, N., Di Pietro, C., Battaglia, R., D’Hooghe, T., Altucci, L., & Dell’Aversana, C. (2023). The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures. Clin Epigenet, 15(1).

Sharma, R., Biedenharn, K. R., Fedor, J. M., & Agarwal, A. (2013). Lifestyle factors and reproductive health: taking control of your fertility. Reproductive Biology and Endocrinology, 11(1), 66.

Wear, H. M., McPike, M. J., & Watanabe, K. H. (2016). From primordial germ cells to primordial follicles: a review and visual representation of early ovarian development in mice. Journal of Ovarian Research, 9(1).

Williams, C. J., & Erickson, G. F. (2000). Morphology and physiology of the ovary (K. R. Feingold, B. Anawalt, M. R. Blackman, A. Boyce, G. Chrousos, E. Corpas, W. W. de Herder, K. Dhatariya, K. Dungan, J. Hofland, S. Kalra, G. Kaltsas, N. Kapoor, C. Koch, P. Kopp, M. Korbonits, C. S. Kovacs, W. Kuohung, B. Laferrère, & M. Levy, Eds.). PubMed;, Inc.

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